St. Mary's dominated Hyannis on Thursday night as the Cardinals cruised for the first-round victory, winning 74-52.
The Cardinals jumped out to a 12-2 lead over Hynannis, who fought back to tie the game at 20-all in the second quarter. But St. Mary's went on a 28-6 run to put the game out of reach.
The No. 2 Cardinals may have a more difficult matchup Friday as they take on No. 3 Sandhills/Thedford in the Class D2 semifinal at 3:45 p.m. at the Devaney Sports Center.